Endocrine Abstracts

Background: Benign cortical and medullary tumours, adrenocortical cancers (ACC), bilateral adrenal hyperplasia, adrenomyelolipomas and metastases are commonly discussed in the differential diagnosis of a tumour in the adrenal bed. This study reports a series of non-adrenal tumours encountered during surgery for expected adrenal tumours.Method: Retrospective review of surgical practice in a tertiary referral centre.Results: Between ...

Aims: Given that the vast majority of surgeons who undertake adrenal surgery in UK have a median workload of 1 case/year there is increasing awareness that the care of such patients should be centralised. This case series illustrates the benefits of multidisciplinary input from surgeons with various expertise involved in the care of complex adrenal cases.Methods: Retrospective review of cases in which endocrine, hepatobiliary and cardiac surgeons collabo...

Historically, bilateral subtotal adrenalectomy was first attempted in patients with failed pituitary surgery for Cushing syndrome. Currently the operation is discussed predominantly in the context of familial phaeochromocytomas in an attempt to preserve sufficient cortical function and avoid life-long steroid dependence. The patients have to be informed of the significance of their particular genetic mutation, the impact of the size of tumours on the intraoperative feasibility...

Screening is expected to diagnose and treat early stage disease in the hope of deriving survival benefits with decreased iatrogenic morbidity. This model is little argued for malignant disease but triggers intense debate for primary hyperparathyroidism (PHPT).Despite an estimated incidence of 20/100 000 persons-years, relatively small numbers of patients undergo parathyroidectomy yearly. In the USA, over 75% of subjects are observed without parathyroid s...

Background: The aim of this report is to describe a fortuitely discovered association between parathyromatosis and occult sclerosing papillary carcinoma of the thyroid.Case description: A 56-year-old woman presented with pyelic relapsed stone, bone pains and iPTH=348 ng but normal calcemia as manifestations of recurrent primary hyperparathyroidism after a right inferior parathyroid adenoma resection done elsewere 6 years ago Sonography showed a 5 mm hypo...

Background: Surgery which was until sixty years ago the only treatment available for Graves’ disease (Gd) is now the last recommended therapeutical option, the number of thyroidectomies (Tx) being in continous decrease. American physicians prefere radioiodine use while their European and Japanese colleagues like better long-term administration of antithyroid drugs.Patients and methods: A retrospective study carried out on 52 consecutive patients wit...

Background: Anecdotal evidence suggests that access to surgical care for primary hyperparathyroidism (PHPT) varies significantly across the UK.Method: A web-based survey was emailed to all members of Parathyroid UK patients’ group.Results: Replies were received from 119 patients (108F: 11M, median age 57) who have had a diagnosis of PHPT for a median for 5 years (3 months–10 years). Majority were diagnosed by the...

Background: The national audit from the British Association of Endocrine Surgeons and the Scandinavian Quality Register of Thyroid and Parathyroid Surgery have reported that 7–17% of patients have hypocalcaemia in the first 6 weeks after thyroid surgery. This study is a snap-shot of management of peri-operative hypocalcaemia using routine Calcichew supplements.Methods: Retrospective review clinical and biochemical data on consecutive p...

IntroductionThere is growing interest in the impact of parathyroidectomy on quality of life in patients with primary hyperparathyroidism (PHPT). The aim of this study was to asses the symptomatic improvement in a cohort of patients with PHPT operated in a single centre in the UK.MethodsA prospective study of consecutive unselected patients with biochemical diagnosis of PHPT was approved by the Local Ethical C...

Background: The presence of striking cardiovascular manifestations was noted in the first descriptions of hyperthyroidism owing to Parry (1825) and Basedow (1840) in the famous Merseburger triad. Hyperthyroidism may either cause cardiac complication in individuals with a normal myocardium (genuine form of disorder) or complicate pre-existing cardiac troubles.Patients and methods: An homogenous series of 49 cardiothyreosis, 11 males and 38 females, aged 1...